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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HLTF
All Species:
8.48
Human Site:
S378
Identified Species:
14.36
UniProt:
Q14527
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.31
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14527
NP_003062.2
1009
113929
S378
E
K
S
K
F
R
M
S
E
L
S
S
S
R
P
Chimpanzee
Pan troglodytes
XP_001138277
1009
113822
S378
E
K
S
K
F
R
M
S
E
L
S
S
S
R
P
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_534300
1106
124184
K475
K
G
K
K
K
Y
T
K
S
E
L
S
S
S
R
Cat
Felis silvestris
Mouse
Mus musculus
Q6PCN7
1003
113298
C372
G
T
P
E
K
S
S
C
T
L
S
Q
L
S
S
Rat
Rattus norvegicus
NP_001099948
974
110023
N343
T
V
K
L
R
G
S
N
T
N
K
T
T
D
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508504
884
99044
K333
S
V
K
K
K
T
M
K
K
G
A
A
M
V
Q
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001090145
999
112576
S368
K
A
K
K
N
E
R
S
T
N
N
K
E
K
S
Zebra Danio
Brachydanio rerio
XP_693071
942
104740
K358
V
R
E
N
G
P
Q
K
K
T
K
T
T
K
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P34739
1061
118357
E426
L
E
D
L
P
G
P
E
V
L
A
E
D
P
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786706
1093
121576
K454
S
K
P
K
G
K
G
K
G
K
K
A
S
G
G
Poplar Tree
Populus trichocarpa
XP_002308876
799
88908
S248
G
K
T
L
A
L
L
S
L
I
A
F
D
K
C
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FF61
881
98598
K330
K
I
E
K
K
G
K
K
R
G
R
G
K
S
S
Baker's Yeast
Sacchar. cerevisiae
P31244
790
91412
T239
P
S
L
V
V
A
P
T
V
A
L
M
Q
W
K
Red Bread Mold
Neurospora crassa
Q7S1P9
1222
137173
P536
L
W
E
E
Y
V
W
P
T
K
D
H
D
D
K
Conservation
Percent
Protein Identity:
100
99.5
N.A.
85.5
N.A.
83.6
81.4
N.A.
71.7
N.A.
64.3
53.1
N.A.
21.1
N.A.
N.A.
34.5
Protein Similarity:
100
99.8
N.A.
88
N.A.
89.7
87.9
N.A.
78.5
N.A.
79.3
69.8
N.A.
41.2
N.A.
N.A.
53.1
P-Site Identity:
100
100
N.A.
20
N.A.
13.3
0
N.A.
13.3
N.A.
13.3
0
N.A.
6.6
N.A.
N.A.
20
P-Site Similarity:
100
100
N.A.
26.6
N.A.
20
20
N.A.
33.3
N.A.
33.3
33.3
N.A.
20
N.A.
N.A.
33.3
Percent
Protein Identity:
33.6
N.A.
N.A.
36
22.7
25.2
Protein Similarity:
50.4
N.A.
N.A.
52.7
40.9
43.9
P-Site Identity:
13.3
N.A.
N.A.
6.6
0
0
P-Site Similarity:
46.6
N.A.
N.A.
13.3
6.6
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
8
0
0
0
8
22
15
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% C
% Asp:
0
0
8
0
0
0
0
0
0
0
8
0
22
15
0
% D
% Glu:
15
8
22
15
0
8
0
8
15
8
0
8
8
0
0
% E
% Phe:
0
0
0
0
15
0
0
0
0
0
0
8
0
0
0
% F
% Gly:
15
8
0
0
15
22
8
0
8
15
0
8
0
8
15
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
8
0
0
0
0
0
0
0
8
0
0
0
0
0
% I
% Lys:
22
29
29
50
29
8
8
36
15
15
22
8
8
22
22
% K
% Leu:
15
0
8
22
0
8
8
0
8
29
15
0
8
0
0
% L
% Met:
0
0
0
0
0
0
22
0
0
0
0
8
8
0
0
% M
% Asn:
0
0
0
8
8
0
0
8
0
15
8
0
0
0
0
% N
% Pro:
8
0
15
0
8
8
15
8
0
0
0
0
0
8
15
% P
% Gln:
0
0
0
0
0
0
8
0
0
0
0
8
8
0
8
% Q
% Arg:
0
8
0
0
8
15
8
0
8
0
8
0
0
15
8
% R
% Ser:
15
8
15
0
0
8
15
29
8
0
22
22
29
22
22
% S
% Thr:
8
8
8
0
0
8
8
8
29
8
0
15
15
0
0
% T
% Val:
8
15
0
8
8
8
0
0
15
0
0
0
0
8
8
% V
% Trp:
0
8
0
0
0
0
8
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _